The objective of the current report produced for the CGIAR Research Program on Aquatic Agricultural Systems (AAS) is to provide basic information on key constraints driving poverty and vulnerability in aquatic agricultural systems in the Tonle Sap region in Cambodia. Six objectives and corresponding research themes are included in the program: sustainable increases in productivity; equitable access to markets; resilience and adaptive capacity; empowering policies and institutions; reduced gender disparity; and expanded benefits for the resource-poor. In this report, the authors review the main aquatic agricultural systems (status, specific policies and strategies, interventions, challenges, and options), then review the main drivers of change. This leads to an identification of plans and strategies important to AAS, with a particular focus on perspectives, gaps and opportunities in national policies, community engagement, increased benefits, adaptive capacity, and gender. This review, of potential interest to decision makers and all development partners, leads to conclusions and recommendations aimed at policymakers and institutional as well as private investors in development.