This material has been put together to assist extension workers and other trainers in facilitating and delivering improved technologies to catfish breeders to ensure profitable ventures. The contents are in simple terms for easy understanding. Learning objectives, activities, learning materials and facilitation methods are well highlighted. Also other key component parts of this module are instruments for pre-and post-course evaluation output evaluation, outcome evaluation and feedback mechanism are provided for periodic improvement of the manual. The learning objectives accomplishment is based on activities properly scheduled and executed. The learning materials are packaged for different hatchery and nursery staff to acquaint them with necessary knowledge and skills for successful monosex tilapia production. The manual is only an instruction device. Therefore, trainer should run the session with necessary adjustment considering the knowledge and experience of the trainees. Training methodologies and technicality of each session are described in detail. These have been carefully planned to ensure active participation of the trainees in the training. Sticking to the methodologies will ensure the active participation of the trainees and expected outcomes of the session will be achieved. The training sessions are arranged in sequence. Necessary information will be discussed within fixed time in each session. If necessary the trainer, in light of his/her own experience, can change or modify the session keeping main topic as it is. However timely starting and ending the session is good for both trainers and trainees. Assessing the success of the training programme is important for both trainers and trainees. Therefore, learning of the trainees needs to be evaluated during the training. Instruments for evaluation assist in assessing how well the set targets have been met; while feedback enables assessment of overall progress leading to achievement of overall objectives.