Fish are a significant source of income and food security in Uganda, highly vulnerable to climate and non-climate related drivers of change. This study examines the vulnerability of the fish sector in Uganda as it relates to the predicted impacts from climate change and variability, using the concept of the value chain. The specific purpose of the study was to identify current and potential impact pathways of climate change and corresponding adaptation strategies in fish value chains. By considering the value chains related to fisheries (Nile Perch and mukene) and pond aquaculture (Nile tilapia and African catfish) in Uganda, this report is able to present context- and sector-specific adaptation strategies for products contributing to domestic food security, livelihoods and national economic development.