This study is a subsection of CPWF-30 (Challenge Program on Water and Food) that centers on investigating the wetland, agriculture, and livelihoods interactions. Chibuto, the floodplain of Changane River in Mozambique is a representative downstream site for the Limpopo sub-catchment. It largely serves as an agro-ecosystem with agricultural, grazing, and fiber collection as the prominent set of ecosystem services. The present analysis is a three-tier framework conceptualized to develop a synoptic overview of spatial, social, and economic elements that governs the system dynamics.