The dynamics of aquatic resources in the canals of Sac Lieu Province, in southern Vietnam, are detailed and synthesized in this study. Nekton and eight environmental parameters were monitored in this province between 2004 and 2006, at 14 sites sampled three times a year. The study area, located along the coastal zone, is characterized by a variable environment subject to saline, freshwater and acidic pulses. The spatiotemporal dynamics of aquatic resources and their relationships with environmental parameters are detailed. The dominance of either freshwater or estuarine fauna, the dynamics of assemblages and the catches of fishers appear to be largely influenced by the management of sluice gates built along the coastal zone.