This study was conducted to assess and compare heavy metals contamination in muscle tissues (edible part) of fish cultured in ponds received fresh, agriculture and sewage drainage water which could poses a threat to human health (consumers). The results of this study indicated no significant accumulation of heavy meals in the fish musculature of the three farms. This study confirms previous reports on the altered water quality of water bodies as a result of discharging the industrial, agricultural and sewage effluents, which affect directly water quality and fish health and might represent a risk for human health indirectly.