This study aims to update the typology of shrimp farms in a province of the Mekong Delta’s coastal area. We analyzed technical and economic characteristics of 170 farms using factor and cluster analysis on the different variables collected during the survey. This allowed us to characterize four different shrimp production systems: intensive commercial and intensive family farms, and the more extensive brackish water polyculture and rice–shrimp farms. The systems differed in their level of intensification, diversification and origin of labor. Labor efficiency was higher in intensive than in extensive farms. The difference in technical practice affected the farmeconomy and specifically its operational monetary cost which was 25–45 times higher in intensive commercial farms than in brackish water polyculture and rice–shrimp farms, respectively. The intensive commercial farms were significantly less affected by virus outbreak than the extensive brackish water polyculture farms. This last shrimp production system presented a very low shrimp yield but a higher capital use efficiency than intensive commercial farms. Rice–shrimp farms, which are located in a specific agro-ecological environment, presented average sustainability characteristics and an average disease occurrence. Results show that technological investments can reduce the vulnerability to disease outbreak and thus reduce the risk usually associated with shrimp farming.