Cage-pond integration system is a new model for enhancing productivity of pond aquaculture system. A field trial was conducted using African catfish (Clarias gariepinus) and Nile tilapia (Oreochromis niloticus) in cages and carps in earthen ponds. This study aimed to assess the production and profitability of different cage-pond integration models of Nile tilapia and African catfish with carps under farmers' conditions and to recommend the best ones for adoption in Nepal.