The objective of this study was to evaluate the effects of fishmeal (FM) replacement with corn protein concentrate (CPC) on growth performance, nutrient utilization, gut morphology and skin coloration of red hybrid tilapia, Oreochromis sp. The results of the present study showed that replacing up to 50% FM with CPC in red hybrid tilapia diet did not show any adverse effects on the growth performance, nutrient utilization efficiency, body-organ indices, whole-body composition, gut histology and tissue coloration of red hybrid tilapia.