Women play essential role in the fisheries sector of Ghana, particularly their involvement in post-harvest activities. However, several factors make them vulnerable to livelihood insecurity. This paper investigates the livelihood vulnerabilities of women in small-scale fisheries in the Gomoa, West District of Ghana by constructing a multi-dimensional livelihood vulnerability index for women fish processorstraders and identifying the factors that make them vulnerable. The Alkire-Foster multi-dimensional measure was used to quantify livelihood vulnerability based on the capital assets identified in the Sustainable Livelihood Framework and alternative livelihood options explored. A beta regression model was used to further examine the effect of other socio-economic characteristics on their vulnerability. The results show that 70 per cent of the women surveyed were multi-dimensionally vulnerable to livelihood insecurity and were deprived in 80 percent of the indicators. The results of the beta regression revealed that differences in multi-dimensional vulnerability are explained by age, household size, household head, access to remittances, and post-harvest losses (fish spoilage). The paper provides valuable insights on how to build resilience of women in small-scale fisheries in Ghana. To sustain and enhance the livelihoods of women in the sector, policy interventions should focus on improving their access to livelihood resources, particularly social capital, as well as building human and institutional capacity.