Nations of the Greater Mekong Subregion need to ‘rethink’ their agricultural industries to meet future food needs, given the social shifts and climate changes that are forecast for the coming decades. With better farming practices, and by managing agriculture within the wider context of natural ecosystems, nations could boost production and increase the wealth and resilience of poor people in rural communities. Demand for food is forecast to double by 2050, as populations swell and people’s dietary choices change. If governments act now, they will be better placed to meet this target and withstand the more severe climatic changes likely to affect the GMS beyond 2050.These are the main messages of the summary report.